MBiol2: Genomics and Evolution MT3

http://oxf.hung.bio/mbiol2-popgen

Lecturer **Tin Hang (Henry) Hung 洪天恒** Fulford Junior Research Fellow, Somerville ****Lecturer in Biology, Magdalen & St Hilda’s [email protected]

Demonstrators Joris Alkemade, Andrea Estandia, Aryaman Gupta, Nilo Merino Recalde

Ellegren & Galtier (2016). Nature Rev Genet. https://www.nature.com/articles/nrg.2016.58

Before the practical

• [ ] Refresh your knowledge from the lectures in MT3:
  • [ ] 34771: Population genetics I: Population structure
  • [ ] 18689: Population genetics II: Selection and genetic control
• [ ] Sleep and eat well.
• [ ] Computers in the Teaching Lab have all the softwares installed. Alternatively, you can bring your own laptop, but please make sure you have installed R (and R studio if you need a GUI) and the R packages listed below.

Activities

In your favourite directory (e.g. Desktop), open three new folders: rosewood, cmh, and adapt. For each activity, in R studio, click on File > New Project > Existing Directory > browse one of these folders. Put all the associated data into the corresponding folders.

Activity 1. How can spatial pattern of genetic diversity inform conservation?

Activity 2. How does genetic diversity distribute across a species’ range?

Activity 3. How can we scan for signals of selection? (optional)

R libraries

The Computer Suite in the teaching lab has already got these packages in R, but if you are using your own laptop, please install these packages: